Past CCTS Courses

2013-2014

Spring 2014 Courses

Undergraduate courses:
CCTS 21002
The Good Physician
Instructors: John Yoon
Time: Mondays/Wednesdays 3:00-4:20 pm
Location: BH H300
This multi-disciplinary course draws insights from medicine, sociology, moral psychology, philosophy, ethics and theology to explore contemporary answers to the age-old question: “How does one become a good physician?” Students will engage relevant literature from across these disciplines to address issues of the goals of medicine, medical professionalism, the doctor-patient relationship, vocation and calling, the role of religion in medicine, and character development in medical education.
Prerequisites: Completed SOSC Sequence
This is an undergraduate course.

CCTS 21003
Topics in Clinical Research
Instructors: Valerie Press and Gavin Hougham
Time: Mondays/Wednesdays 1:30-2:50 pm
Location: BH H300
This course provides an overview of clinical research subject matter from the history and ethics of clinical research to the types and practices of contemporary clinical research. How does clinical research differ from other research traditions? What is special about clinical research? What types of questions can be answered by clinical research (and what questions not)? What types of ethical oversight over the responsible conduct of research have arisen over the years? We will learn how to read and critique clinical research, survey the major types of clinical research designs, and the differences between hypothesis generation and hypothesis testing. Finally, we provide an overview of the mechanics of developing and implementing clinical research, including grant writing, regulatory issues, and quality assurance. Along the way, we will be teaching core statistical concepts including prevalence, risk ratios, and sensitivity and validation techniques. The objectives are for students to obtain an understanding of how and why to perform clinical research and to do so in an ethical and responsible manner.
Prerequisites: Completed social sciences core
This is an undergraduate level course.

Graduate/mixed-level courses:
CCTS 40006
Pharmacogenomics: Discovery and Implementation
Instructors: R. Stephanie Huang and M. Eileen Dolan
Time: Mondays/Wednesdays 10:30-11:50 am
Location: TBD
Pharmacogenomics is aimed at advancing our knowledge of the genetic basis for variable drug response. Advances in genetic knowledge gained through sequencing have been applied to drug response, and identifying heritable genetic variants that predict response and toxicity is an area of great interest to researchers. The ultimate goal is to identify clinically significant variations to predict the right choice and dose of medications for individuals--"personalizing medicine." The study of pharmacogenomics is complicated by the fact that response and toxicity are multigenic traits and are often confounded by nongenetic factors (e.g., age, co-morbidities, drug-drug interactions, environment, diet). Using knowledge of an individual's DNA sequence as an integral determinant of drug therapy has not yet become standard clinical practice; however, several genetics-guided recommendations for physicians have been developed and are highlighted. The ethics and economics of pharmacogenomics are also discussed.
Prerequisites: BIOS 20187
This course is open to both graduate and fourth-year undergraduate students. Consent of instructor is required for second and third-year undergraduates. Course meets requirement for Biological Sciences Major as part of the Cancer Specialization.

CCTS 42000
Introduction to Clinical Research Informatics
Instructors: Sameer Badlani, Sam Volchenbaum, David McClintock, Cheng-Kai Kao
Time: Fridays, 3:30-5:00 pm
Location: BH H300
The course is an introductory survey of fundamentals of information technology as applied to health care. The course will focus on technology’s impact on the patient, health care provider, and the hospital. In addition to the sources and forms of clinical and provider data, the course will expose the student to the use of data in measuring outcomes and system performance. Portions of the course will be devoted to decision support, system integration, and educational applications. New and emerging uses of technology will also be discussed, along with security and compliance for protected health information. There will be a special session devoted to pathology informatics. The course is ideal for fellows, post-docs, residents, junior faculty, or anyone looking for a broad introduction to clinical informatics.

CCTS 47003
Advanced Community Based Participatory Research (CBPR) Training Program-3
Instructors: Deborah Burnet, Doriane Miller
Various Times
Location: TBD
The Advanced CBPR Training Program is designed to help meet the growing need and demand for educational resources that help build the knowledge and skills needed to develop and sustain effective CBPR partnerships. The Program consists of six sessions that are offered on various Fridays throughout the year. Lunch will be provided at each session.
Online registration for the CBPR Training Program is also required.
Registrants who wish to receive 025 units of course credit must have registered for CCTS 47001 and CCTS 47002 in the winter quarter as well as for CCTS 47003 in the spring quarter.

Winter 2014 Courses

CCTS 21000
Medical Sociology
Instructor: Gavin Hougham, PhD
Tuesday/Thursday 1:30 – 2:50 pm
Location TBA
This course surveys the literature in several core areas of medical sociology with a focus mostly on social behavior and health, and secondarily on the institutions and organizations associated with the delivery of health care and medical education. The class will examine social constructions of medical knowledge and illness, the rise of medicine as a powerful institution, and social epidemiology. We will also discuss the organization of health care and health care utilization. Students will obtain an understanding of key concepts, theories, methods, and research findings in these areas, and most importantly will internalize an understanding of how “social” health and illness is.

CCTS 21003
Topics in Clinical Research
Instructor: Valerie Press, MD, MPH
**Note: This course has been postponed until Spring 2014
This course provides an overview of clinical research subject matter from the history and ethics of clinical research to the types and practices of contemporary clinical research. How does clinical research differ from other research traditions? What is special about clinical research? What types of questions can be answered by clinical research (and what questions not)? What types of ethical oversight over the responsible conduct of research have arisen over the years? We will learn how to read and critique clinical research, survey the major types of clinical research designs, and the differences between hypothesis generation and hypothesis testing. Finally, we provide an overview of the mechanics of developing and implementing clinical research, including grant writing, regulatory issues, and quality assurance. Along the way, we will be teaching core statistical concepts including prevalence, risk ratios, and sensitivity and validation techniques. The objectives are for students to obtain an understanding of how and why to perform clinical research and to do so in an ethical and responsible manner.
Note: This is an undergraduate level course.

CCTS 42000
Introduction to Clinical Research Informatics
**Note: This course has been postponed until Spring 2014
The course is an introductory survey of fundamentals of information technology as applied to health care. The course will focus on technology’s impact on the patient, health care provider, and the hospital. In addition to the sources and forms of clinical and provider data, the course will expose the student to the use of data in measuring outcomes and system performance. Portions of the course will be devoted to decision support, system integration, and educational applications. New and emerging uses of technology will also be discussed, along with security and compliance for protected health information. There will be a special session devoted to pathology informatics. The course is ideal for fellows, post-docs, residents, junior faculty, or anyone looking for a broad inroduction to clinical informatics.
This course is approved to offer a maximum of 15 AMA PRA Category 1 Credits™ to physician attendees. Please use the following activity number when submitting documentation to the Center for CME: 04-00-003

CCTS 47001 and CCTS 47002
Advanced Community-Based Participatory Research (CBPR) Training Program 1 and 2
Course schedule
Friday 12:00 – 1:00 pm
W229
The Advanced CBPR Training Program is designed to help meet the growing need and demand for educational resources that help build the knowledge and skills needed to develop and sustain effective CBPR partnerships. The Program consists of six sessions that are offered on various Fridays throughout the year. Lunch will be provided at each session. Online registration for the CBPR Training Program is also required.
Registrants who wish to receive 025 units of course credit must register for CCTS 47001 and CCTS 47002 in the winter quarter as well as for CCTS 47003 in the spring quarter.

CCTS 43000
Introduction to Global Health
This course provides an overview of global health from the historical perspective to the current state of global health. The course features weekly guest lecturers with a broad range of expertise in the field: topics include the social and economic determinants of health, the economics of global health, global burden of disease, and globalization of health risks, as well as the importance of ethics, human rights, and diplomacy in promoting a healthier world. The course is designed for graduate-level students and senior undergraduates with an interest in global health work in resource-limited settings.

CCTS 40300
Signal Transduction and Disease
Topics include receptor ligands, membrane receptor tyrosine kinases and phosphatases, G proteins, proto-oncogenes, signaling pathways, cytoplasmic protein kinases and phosphatases, transcription factors, receptor-nucleus signaling, development and cancer, genetic dissection of signaling pathways, cell growth and cell proliferation, interplay of cell cycle regulators, cell cycle progression and apoptosis, and sensing of hypoxia and mechanical stimuli. The role of signaling in disease is a theme throughout the course.
The course description above is the most recent available. Descriptions from past years can be found athttp://catalogs.uchicago.edu or on the website for your graduate school or professional program.

CCTS 40200
Cancer Bio-2: Mol Mech Cancer Biology
This course provides students with an in-depth understanding of how key cellular processes are deregulated in cancer and the molecular mechanisms underpinning these defects. The course covers cell cycle checkpoint control, cell death, tumor suppressor and oncogene function, DNA repair mechanisms, epigenetics of cancer, nuclear hormone receptor activity in cancer, tumor metabolism, hypoxia responses, angiogenesis and metastasis. In addition to material covered in formal lectures, discussion sessions cover tumor stem cells, "oncogene addiction," inflammatory responses, cancer therapeutics, mouse models of human cancer and other topical subjects relevant to understanding tumor initiation and progression, as well as how current research may facilitate cancer treatment.

Fall 2013 Courses

CCTS 40004
Advanced Clinical Pharmacology I
Instructor: Michael Maitland
Thursdays 3:30 – 4:50pm
M214
This course provides an interactive introduction to fundamental principles of the practice of clinical pharmacology relevant to drug development and personalized therapeutics. Topics include: pharmacokinetics, drug metabolism, protein binding, absorption and renal and hepatic elimination, pharmacodynamics, introduction to modeling methods, evaluation of adverse events, and pre-clinical and clinical elements of drug development. The course combines directed readings, guest lectures, and problem sets.

CCTS 46001
Fundamentals of Quality Improvement and Patient Safety
Instructors: Chad Whelan and Laura Botwinick
Tuesdays 5:00 – 6:30pm
H300

Quality Improvement & Patient Safety 101 is being offered this Fall. The course was designed for faculty and staff at University of Chicago Medicine with the support of the Center for Clinical and Translational Science (CCTS). The course provides an overview of concepts and methodologies for improving the quality and safety of care. Participants will design quality improvement projects using skills learned in class. In addition, UCMC leaders will speak on key topics throughout the course.

  • Participants will become familiar with tools for improving quality of care and service delivery, such as the Model for Improvement and Lean Performance Improvement.
  • Participants will design an actual quality improvement project and complete a personal improvement project using skills learned in the class.
  • Participants will understand the factors impacting the delivery of safe and high quality care in health care organizations such as teamwork, good communication and organization culture.
  • Participants will understand “Systems Thinking” and other key concepts in patient safety such as Human Factors and Reliability.
  • Participants will understand the key role of QI in today’s health care environment as a mechanism for improving organizational effectiveness and the patient experience.

The course meets for 10 weeks on Tuesday evenings from 5:00 – 6:30 p.m., beginning on October 1, 2013. The course is part of a series of courses (others to be designed) leading to a Certificate in QI & PS. Participation in at least 7 of the 10 weeks qualifies attendees to be eligible for the certificate once the other courses are available.
This course has been approved for CME credit - a maximum of 15 AMA PRA Category 1 Credits™.
Instructors for the course are Chad Whelan, MD, Associate Professor of Medicine and Associate Chief Medical Officer for Performance Improvement and Innovation; and Laura Botwinick, Director of the Graduate Program in Health Administration and Policy (GPHAP) and Fellow, Institute for Healthcare Improvement (IHI).