Past CCTS Courses

2015-2016

Spring 2016 Courses

CCTS 47003/01
Advanced Community Based Participatory Research (CBPR) Training Program 3
Instructor: Deborah Burnet, Doraine Miller
Time: Various
Locations: TBD
The Advanced CBPR Training Program is designed to help mee the growing need and demand for educational resources that help build the knowledge and skills needed to develop and sustain effective CBPR partnerships. 

Registrants who wish to receive 025 units of course credit must register for CCTS 47001 in the fall, CCTS 47002 in the winter, & CCTS 47003 in the spring. They must also register online here.

CCTS 21003/01
Topics in Clinical Research
Instructor: Valerie Press
Time: Mondays and Wednesdays, 1:30-2:50PM
Location: BH W300
This course provides an overview of clinical research subject matter from the history and ethics of clinical reseach to the types and practice of contemporary clinical research.  How does clinical research differ from other research traditions? What is special about clinical research? What types of questions can be answered by clinical research, and what questions not? What types of ethical oversight over the responsible conduct of reserach have arisen over the years? We will learn how to read and critique clinical research, survey the major types of clinical research designs, and the differences between hypothesis generation and hypothesis testing.  Finally, we provide an overview of the mechanics of developing and implementing clinical research, including grant writing, regulatory issues, and quality assurance.  Along the way, we will be teaching core statistical concepts including prevalence, risk ratios, and sensitivity and validation techniques.  The objectives are for students to obtain an understanding of how and why to preform clinical research and to do so in an ethical and responsible manner.

CCTS 40006/01
Pharmacogenomics: Discovery and Implementation

Instructor: R. Stephanie Huang, Barbara Stranger
Time: Mondays and Wednesdays, 10:30-11:50AM
Location: BSLC 305
Pharmacogenomics is aimed at advancing our knowledge of the genetic basis for variable drug response. Advances in genetic knowledge gained through sequencing have been applied to drug response, and identifying heritable genetic variants that predict presonse and toxicity is an area of great interest to researchers. The ultimate goal is to identify clinically significant variations to predict the right choice and dose of medications for individuals--"personalizing medicine."  The study of pharmacogenomics is complicated by the fact that response and toxicity are multigenic traits and are often confounded by nongenetic factors (e.g., age, co-morbidities, drug-drug interactions, environment, diet). Using knowledge of an individual's DNA sequence as an integral determinant of drug therapy has not yet become standard clinical practice; however, several genetics-guided recommendations for physicians have been developed and are highlighted.  The ethics and economics of pharmacogenomics are also discussed.

Prerequisites: BIOS 20187 and consent of the instructor, 3rd - 4th year undergraduates only. Course meets requirements for Biological Sciences Major as part of the Cancer Specialization.

CCTS 21002/01
The Making of the "Good Physician": Multidisciplinary Perspectives on Vocation, Calling and the Pursuit of Clinical Excellence

Instructor: John Yoon
Time: Mondays and Wednesdays 1:30-2:50PM
Location: Mitchell Hospital W-717
This multi-disciplinary course draws insights from medicine, sociology, moral psychology, philosophy, ethics and theology to explore contemporary answers to the age-old question: "How does one become a good physician?" Students will engage relevant literature from across these disciplines to address issues of the goals of medicine, medical professionalism, the doctor-patient relationship, vocation and calling, the role of religion in medicine, and character development in medical education.

CCTS 32411/01
Mediation, Moderation, and Spillover Effects

Instructor: Hong Guanglei
Time: Tuesdays 1:30-4:20PM
Location: TBD
This course is designed for graduate students and advanced undergraduate students from social sciences, statistics, public health science, public policy, and social service administration who will be or are currently involved in quantitative research.  Questions about why a treatment works, for whom, under what conditions, and whether one individual's treatment could affect other individuals' outcomes are often key to the advancement of scientific knowledge. We will clarify the theoretical concepts of mediated effects, moderated effects, and spillover effects under the potential outcomes framework.  The course introduces cutting-edge methodological approaches and contrasts them with conventional strategies including multiple regression, path analysis, and structural equation modeling. The course content is organized around application examples. The textbook "Causality in a Social World: Moderation, Mediation, and Spill-Over" (Hong, 2015) will be supplemented with other readings reflecting latest developments and controversies. Weekly labs will provide tutorials and hands-on experiences. All students are expected to contribute to the knowledge building in class through participation in presentations and discussions. Students are encouraged to form study groups, while the written assignments are to be finished and graded on an individual basis. Intermediate Statistics, Indtroduction to Causal Inference, and their equivalent are prerequisites.

CCTS 38300/01
Health Economics and Public Policy

Instructor: David Meltzer
Time: Tuesday and Thursdays 1:30-2:50PM
Location: PBPL 140C
This course analyzes the economics of health and medical care in the United States with particular attention to the role of government.  The first part of the course examines the demand for health and medical and the structure and the consequences of public and private insurance.  The second part of the course examines the supply of medical care, including professional training, specialization and compensation, hospital competition, and finance and the determinants and consequences of technological change in medicine.  THe course concludes with an examination of recent initiatives for health care reform.

Winter 2016 Courses

CCTS 40200/01
Cancer Bio-2: Mol Mech Cancer Biology
Instructor: Kay MacLeod
Time: Mondays, Wednesdays, Fridays 10:30 – 12:20pm
Location: BSLC 240
This course provides students with an in-depth understanding of how key cellular processes are deregulated in cancer and the molecular mechanisms underpinning these defects. The course covers cell cycle checkpoint control, cell death, tumor suppressor and oncogene function, DNA repair mechanisms, epigenetics of cancer, nuclear hormone receptor activity in cancer, tumor metabolism, hypoxia responses, angiogenesis and metastasis. In addition to material covered in formal lectures, discussion sessions cover tumor stem cells, "oncogene addiction," inflammatory responses, cancer therapeutics, mouse models of human cancer and other topical subjects relevant to understanding tumor initiation and progression, as well as how current research may facilitate cancer treatment.

CCTS 40300/01
Signal Transduction and Disease

Instructors: Nicholai Dulin
Time: Mondays, Wednesdays 3:00 - 4:20 PM
Location: BH-N701
Topics include receptor ligands, membrane receptor tyrosine kinases and phosphatases, G proteins, proto-oncogenes, signaling pathways, cytoplasmic protein kinases and phosphatases, transcription factors, receptor-nucleus signaling, development and cancer, genetic dissection of signaling pathways, cell growth and cell proliferation, interplay of cell cycle regulators, cell cycle progression and apoptosis, and sensing of hypoxia and mechanical stimuli. The role of signaling in disease is a theme throughout the course

CCTS 40400/20400
Health Disparities in Breast Cancer

Instructor: Eileen Dolan, Suzanne Conzen
Time: Mondays, Wednesdays 10:30-11:50 am
Location: BSLC 202
Across the globe, breast cancer is the most common women’s cancer. In the last two decades, there have been significant advances in breast cancer detection and treatment that have resulted in improved survival rates. Yet, not all populations have benefited equally from these improvements, and there continues to be a disproportionate burden of breast cancer felt by different populations. In the U.S., for example, white women have the highest incidence of breast cancer but African-American women have the highest breast cancer mortality overall. The socioeconomic, environmental, biological, and cultural factors that collectively contribute to these disparities are being identified with a growing emphasis on health disparities research efforts.  In this 10-week discussion-based course students will meet twice weekly and cover major aspects of breast cancer disparities. 

CCTS 43000 (BIOS 29294)
Introduction to Global Health

Instructor: Chrissy Babcock, Sola Olopade
Time: Tuesdays and Thursdays, 12:00pm-1:20pm
Location: BSLC 324
This course provides an overview of global health from the historical perspective to the current state of global health. The course features weekly guest lecturers with a broad range of expertise in the field: topics include the social and economic determinants of health, the economics of global health, global burden of disease, and globalization of health risks, as well as the importance of ethics, human rights, and diplomacy in promoting a healthier world. The course is designed for graduate-level students and senior undergraduates with an interest in global health work in resource-limited settings.

Open to undergraduate and graduate students.

CCTS 45300
Methods of Systematic Review
Instructor: Goutham Rao, Elbert Huang
Time: Thursdays, 1:30 pm-3:30 pm
Location: M214
This short course will introduce you to methods used to develop systematic reviews (both qualitative and quantitative i.e. meta-analysis) which have become increasingly popular in answering important health related questions. Students will work through the process of developing a review, including developing a sound clinical question, identifying, selecting, and assessing the quality of studies, identifying heterogeneity, and pooling results. Additional topics including identifying publication bias, subgroup and sensitivity analyses and emerging methods for meta-analysis will be covered very briefly. Students will also receive a brief introduction to meta-analysis software. 

Course runs from January 7 through 28. If you are interested in enrolling or auditing this course, please contact Kelsey Bogue at kbogue@bsd.uchicago.edu.

CCTS 47002
Advanced Community Based Participatory Research (CBPR) Training Program - 2

Instructor: Deborah Burnet, Doriane Miller
Time: Various
Location: Series -  TBD
The Advanced CBPR Training Program is designed to help meet the growing need and demand for educational resources that help build the knowledge and skills needed to develop and sustain effective CBPR partnerships. The Program consists of six sessions that are offered on various Fridays throughout the year. Lunch will be provided at each session.

Registrants who wish to receive 025 units of course credit must register for CCTS 47001 in the fall, CCTS 47002 in the winter, & CCTS 47003 in the spring. They must also register online here.

Fall 2015 Courses

CCTS 46001
Fundamentals of Quality Improvement and Patient Safety

Instructor: Andrew Davis, Laura Botwinick
Time: Tuesdays, 5:00-6:30 pm, October 13 - November 24
Location: BH-H300
Quality Improvement & Patient Safety was designed for faculty and staff at University of Chicago Medicine with the support of the Center for Clinical and Translational Science (CCTS). The course provides an overview of concepts and methodologies for improving the quality and safety of care. Participants will design quality improvement projects using skills learned in class. In addition, UCMC leaders will speak on key topics throughout the course. 

  • Participants will become familiar with tools for improving quality of care and service delivery, such as the Model for Improvement and Lean Performance Improvement.
  • Participants will design an actual quality improvement project and complete a personal improvement project using skills learned in the class.
  • Participants will understand the factors impacting the delivery of safe and high quality care in health care organizations such as teamwork, good communication and organization culture.
  • Participants will understand “Systems Thinking” and other key concepts in patient safety such as Human Factors and Reliability.
  • Participants will understand the key role of QI in today’s health care environment as a mechanism for improving organizational effectiveness and the patient experience.

This course will run from 10/13/2015-11/24/2015 and is comprised of seven classes total. Faculty, staff, and students/trainees at the University of Chicago Medical Center are welcome to audit the course and should contact Kelsey Bogue at kbogue@bsd.uchicago.edu to register. To earn 025 credits, please enroll in the course at classes.uchicago.edu.

CCTS 40004
Advanced Clinical Pharmacology I: Pharmacokinetics, Pharmacodynamics and Drug Development

Instructor: Navin Pinto, Manish Sharma
Time: Thursdays, 3:30-4:50 pm
Location: BH-M214
This course provides an interactive introduction to fundamental principles of the practice of clinical pharmacology relevant to drug development and personalized therapeutics. Topics include: pharmacokinetics, drug metabolism, protein binding, absorption and renal and hepatic elimination, pharmacodynamics, introduction to modeling methods, evaluation of adverse events, and pre-clinical and clinical elements of drug development.

PQ: MEDC 30777, equiv Intro to Pharm., approval.

CCTS 47001
Advanced Community Based Participatory Research (CBPR) Training Program 1

Instructor: Deborah Burnet, Doriane Miller
Time: Various
Location: Various
The goal of health-related research is to improve the lives of people in the community studied. In traditional research, the community is not actively involved in designing the projects. Community-based participatory research is a partnership approach to research that equitably involves community members, organizational representatives, and academic researchers in all aspects of the research process. The Advanced CBPR Training Program is designed to help meet the growing need and demand for educational resources that help build the knowledge and skills needed to develop and sustain effective CBPR partnerships. The Program consists of six sessions that are offered on various Fridays throughout the year.

Registrants who wish to receive 025 units of course credit must enroll through the University Registrar's office for CCTS 47001 in the fall, CCTS 47002 in the winter, and CCTS 47003 in the spring. Participants must also register online here whether or not they choose to take the course for credit. 

CCTS 47005
Methods in Health and Biomedical Informatics

Instructor: Samuel Volchenboum, David McClintock
Time: Thursdays, 2:00-4:00 pm
Location: Northwestern Downtown Campus, TBA
Most Health and Biomedical Informatics (HBMI) Graduate Programs around the country have independently come to the conclusion that the computational methods that informatics graduate students need to be familiar with is too broad and numerous to be addressed by a series of independent courses. Therefore, most programs have created a set of integrated courses that expose the students to a wide variety of informatics methods in short modules. Typically, these required methods series are organized as a series of required courses taken during the first year of graduate study. This course is the result of discussions by Health and Biomedical Informatics researchers and educators from the Chicago Biomedical Informatics Training (CBIT) initiative. This course is designed as first course of a year-long sequence.

PQ: Basic understanding of Python programming language; prior or simultaneous enrollment in Health & Biomedical Informatics (HBMI) intro course. Course begins 9/24/2015 and runs for 10 weeks at Northwestern downtown campus. Send questions about enrollment to kbogue@bsd.uchicago.edu.

CCTS 47100/27100
Bioinformatics Analysis of Integrative 'Omics Data

Instructor: Samuel Volchenboum, Jorge Andrade
Time: December 2-5, 2015
Location: Workshop - Harper Court 1121; Other events - TBA
The workshop will focus on the integration of multiple ‘omic/clinical datasets to answer complex questions on Biomedical research. Strong focus will be placed on the use of NGS based ChIP-seq analysis pipeline and its integration with gene expression and clinical information.

Instructor consent is required. Students seeking academic credit for the course must submit the online application by Friday, September 18 at 5 pm CST and will be notified by Friday, September 25 whether they have been admitted to the course. Interested participants must apply online and submit a CV/resume for review. Contact kbogue@bsd.uchicago.edu with any questions. 

Summer 2015 Courses

CCTS 45000
Intro to Biostatistics
Instructors: Sydeaka Watson
Time: Tuesdays/Wednesdays/Thursdays, 3:00-4:20 pm
Location: BSLC 324
This course will provide an introduction to the basic concepts of statistics as applied to the bio-medical and public health sciences. Emphasis is on the use of interpretation of statistical tools for data analysis. Topics include (i) descriptive statistics; (ii) probability and sampling; (iii) the methods of statistical inference; and (iv) an introduction to linear and logistics regression.

Pre-requisite of 2 quarter of pre-calculus required. Class will meet 7/7/15 – 8/20/15.

CCTS 45100/01
Clinical Epidemiology
Instructors: Brian Chiu, Diane Lauderdale
Time: Tuesdays/Thursdays, 9:00-11:00 am
Location: BSLC 202
Clinical epidemiology is the “application of epidemiologic principles and methods to problems encountered in clinical medicine.” This course introduces the basic principles of epidemiologic study design, analysis and interpretation, with a particular focus on clinical applications. The course includes lectures and discussions based on critical appraisal of significant research articles. The course is primarily intended for, but not restricted to, students with prior clinical training. Health Studies 30700 and 30900 may not both be taken for credit, either will fulfill the basic epidemiology requirement for the MSCP in Health Studies and either will serve as the epidemiology prerequisite for Health Studies 31001.

Introductory statistics recommended. Class will meet 7/7/15 – 8/20/15.

CCTS 45200/01
Fundamentals of Health Services Research: Theory, Methods & Applications
Instructors: David Meltzer, Marshall Chin
Time: Mondays/Tuesdays/Wednesdays/Thursdays/Fridays, 1:00-2:30 pm
Location: Billings Hospital, H300
This course is designed to provide an introduction to the fundamentals of health services research. The basic concepts of health services research will be taught with emphasis on both their social scientific foundations and the methods needed for their practical application to empirically relevant research. Theoretical foundations will draw on principles from economics, sociology, psychology, and the other social sciences. Methodological topics to be covered will include techniques for data collection and analysis, including outcomes measurement, survey methods, large data set research, population-based study design, community based participatory research, research based in clinical settings, qualitative methods, cost-effectiveness analysis, and tools of economic and sociological analysis. The theoretical and empirical techniques taught will emphasize those relevant to the examination of health care costs, quality, and access. Major applications will include: measurement and improvement of health care quality, analysis of health disparities, analysis of health care technology, and analysis of health care systems and markets. This course will meet for 1.5-hour sessions, five times per week for six weeks.

Class meets 7/6/15 – 8/21/15. Cross list: PPHA 47900, PBHS 35000